An introduction to the analysis of acid base titrations

Charge balance is used in the fourth equation, where the left hand side represents the total charge of the cations and the right hand side represents the total charge of the anions:

An introduction to the analysis of acid base titrations

Theoretical background[ edit ] The acid dissociation constant for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction.

The value of pKa also depends on molecular structure of the acid in many ways. For example, Pauling proposed two rules: Other structural factors that influence the magnitude of the acid dissociation constant include inductive effectsmesomeric effectsand hydrogen bonding.

Hammett type equations have frequently been applied to the estimation of pKa. In particular, the pH of a solution can be predicted when the analytical concentration and pKa values of all acids and bases are known; conversely, it is possible to calculate the equilibrium concentration of the acids and bases in solution when the pH is known.

These calculations find application in many different areas of chemistry, biology, medicine, and geology. For example, many compounds used for medication are weak acids or bases, and a knowledge of the pKa values, together with the water—octanol partition coefficientcan be used for estimating the extent to which the compound enters the blood stream.

Acid dissociation constants are also essential in aquatic chemistry and chemical oceanographywhere the acidity of water plays a fundamental role.


In living organisms, acid—base homeostasis and enzyme kinetics are dependent on the pKa values of the many acids and bases present in the cell and in the body. In chemistry, a knowledge of pKa values is necessary for the preparation of buffer solutions and is also a prerequisite for a quantitative understanding of the interaction between acids or bases and metal ions to form complexes.

Experimentally, pKa values can be determined by potentiometric pH titrationbut for values of pKa less than about 2 or more than about 11, spectrophotometric or NMR measurements may be required due to practical difficulties with pH measurements. The equilibrium constant for this dissociation reaction is known as a dissociation constant.

An introduction to the analysis of acid base titrations

Acetic acida weak aciddonates a proton hydrogen ion, highlighted in green to water in an equilibrium reaction to give the acetate ion and the hydronium ion. The acid loses a proton, leaving a conjugate base; the proton is transferred to the base, creating a conjugate acid.

Acids and bases are thus regarded simply as donors and acceptors of protons respectively. A broader definition of acid dissociation includes hydrolysisin which protons are produced by the splitting of water molecules.

According to Lewis 's original definition, an acid is a substance that accepts an electron pair to form a coordinate covalent bond.Standard Methods for the Examination of Water and Wastewater © Copyright by American Public Health Association, American Water Works Association, Water.

In today's experiment, NaOH, a base, is the standard solution. Sodium hydroxide will be added to an unknown acid. The unknown acid and the base reacts and forms salt and water.

This type of reaction is called neutralization: NaOH + HA > H2O + NaA HA is an abbreviation for an unknown acid. Volumetric (Titrimetric) Analysis.

General Principles In titrimetric analysis volumetrically measures the amount of reagent, often called a titrant, required to complete a chemical reaction with the analyte.

for acid-base titrations, the pH or pOH is plotted versus base or acid titrant volume. Titration curves may be plotted from. AP Chemistry is an in-depth, fast-paced second-year chemistry course for advanced, science-oriented students.

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The course will provide students with a thorough grounding in chemical principles and quantitative reasoning, with an emphasis on inorganic chemistry. A titration can be performed with almost any chemical reaction for which the balanced chemical equation is known. Here, we will consider titrations that involve acid-base reactions.

In a titration, one reagent has a known concentration or amount, while the other reagent has an unknown concentration or amount. ACID BASE TITRATION OBJECTIVES 1.

An introduction to the analysis of acid base titrations

To demonstrate the basic laboratory technique of titration 2. To learn to calculate molarity based on titrations INTRODUCTION Molarity (M) or molar concentration is a common unit for expressing the concentration of solutions.

Thomas Greenbowe | Department of Chemistry and Biochemistry